![]() ![]() ![]() Members share a conserved protein structure, including a Structural properties of ClC-2ĭespite wide functional diversity, ClC family Within a 391-bp region upstream, theįirst three of four GC boxes are conserved in human ClC-2, as The ClC-2 promoter belongs to a GC-rich andġ,930-bp region, one of three CAAT boxes is close to the ClC-2Ĭoding sequence, and the other two are at the middle ( 44). Mutation and DNA rearrangement ( 27, 43). Gene suggested that ClC-2 may have evolved by gene duplication, A previous study ( 42) on the possible evolution of ClC-2 The major transcription start site of the ClC-2 gene hasīeen identified, and is localized 100 bp upstream of the putative Which is composed of 898 amino acids and is located in chromosomeģq27.1. The ClC-2 protein is encoded by the CLCN2 gene, Molecular properties of ClC-2 CLCN2 and ClC-2 promoter The molecular, functional and physiological properties of ClC-2, inĪddition to mechanisms involved in the regulation of ClC-2 andĭiseases associated with ClC-2. Leukoencephalopathy, epilepsy and diabetes mellitus. Impaired intestinal mucosa barrier, leukemia, cystic fibrosis, The testes, azoospermia, lung cancer, constipation, repair of Retina, Sjögren's syndrome, age-related cataracts, degeneration of Several molecular, functional and physiological properties, and beĪssociated with several diseases, including degeneration of the In addition, ClC-2 can regulate cellĬontrol response to swelling ( 11, 36– 39),Īnd regulates post-synaptic responses to GABA and glycine ( 11, 40, 41).Īlthough ClC-2 has a wide variety of properties andįunctions, repots of CLC-3 prior to 1994 are limited, with only sixĪttracted increasing attention as ClC-2 was understood to possess ( 32, 33) and rat trabecular meshwork ( 34). ClC-2 is a two-pore homodimeric,ĬlC-2 can be activated by hyperpolarization ( 3, 9),Ĭell swelling ( 2, 9), extracelluar hypotonicity ( 2) and extracellular acidificationĮxpressed ( 3, 11), including in ureteric bud cells Heart and brain ( 2, 3) and then from the rabbit heart Members of the ClC family, and was initially isolated from the rat Membrane, and ClC proteins are encoded by genes of the ClC family.ĬlCs have nine family members, which are classified into threeĭistinct subfamilies: ClC-1, ClC-2, ClC-Ka/K1 and ClC-Kb/K2 ClC-3,ĬlC-4 and ClC-5 and ClC-6 and ClC-7 ( 1). The determination of CLCN2 is required to prevent and treat several diseases associated with ClC‑2.Ĭhloride channels (ClCs) are a type of permeableĬhannel protein for chloride ions or other anions on the cell It was concluded that future investigations of ClC‑2 are likely to be focused on developing specific drugs, activators and inhibitors regulating the expression of ClC‑2 to treat diseases associated with ClC‑2. The review then discusses the diseases associated with ClC‑2, including degeneration of the retina, Sjögren's syndrome, age‑related cataracts, degeneration of the testes, azoospermia, lung cancer, constipation, repair of impaired intestinal mucosa barrier, leukemia, cystic fibrosis, leukoencephalopathy, epilepsy and diabetes mellitus. The effects of ClC‑2 on the digestive, respiratory, circulatory, nervous and optical systems are also discussed, in addition to the mechanisms involved in the regulation of ClC‑2. The present review discusses the molecular properties of ClC‑2, including CLCN2, ClC‑2 promoter and the structural properties of ClC‑2 protein physiological properties functional properties, including the regulation of cell volume. Such as hsa:351 for human amyloid beta gene.Chloride channel 2 (ClC-2) is one of the nine mammalian members of the ClC family. Viral mature peptides appear in KEGG pathway maps and as drug targets and are given KOs.Įach GENES entry is identified by the combination of organism code and gene identifier in the form of The viral peptide (vp) category is a collection of mature peptides processed from genome-encoded polyproteins, which are not usually found as separate entries in the public databases such as NCBI and UniProt. They are used to define new KOs that are not covered by complete genomes (see KO database). The Addendum category is a PubMed-based collection of protein sequences whose functions are experimentally characterized. Three- or four-letter organism code for cellular organisms ![]()
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